In the treatment of heart failure severe first-dose hypotension on introduction 25mg an ACE inhibitor is common in patients on loop diuretics, but their temporary withdrawal may cause rebound pulmonary oedema. Thus an initial dose of 6, thuoc captopril bp 25mg. Again, in the Kenya higher doses of up to mg three times daily have been suggested. Please talk to your doctor before taking Captopril if any captopril the above apply to you, even if they applied only in the past, thuoc captopril bp 25mg.
Taking Captopril with other medicines The effect of Captopril may be changed if you take it at the same time as other medicines. Talk to your doctor before thuoc Captopril if you are taking any of the following medicines: Captopril may increase the levels of potassium in your blood.
Taking Captopril at the same time may cause low blood pressure.
These medicines may thuoc Captopril work less well, thuoc captopril bp 25mg. Medicines used for the treatment of depression e. Please tell your doctor 25mg pharmacist if you are taking, captopril have recently taken, any other medicine - even those not prescribed. ACE inhibitor-induced cough should be considered in the differential diagnosis of cough.
There is concern, on theoretical grounds, that patients with aortic stenosis might be at particular thuoc of decreased coronary perfusion when treated with vasodilators because they do not develop as much afterload reduction as others. In patients undergoing major surgery or during anesthesia with agents that produce hypotension, captopril will block angiotensin Venlafaxine hcl drug prices formation secondary to compensatory renin release.
If hypotension occurs and is considered to be due to this mechanism, it can be corrected by volume expansion, thuoc captopril bp 25mg. Hemodialysis Recent clinical observations have shown an association of hypersensitivity-like anaphylactoid reactions during hemodialysis with high-flux dialysis membranes e. In these patients, consideration should be given to using a different type captopril dialysis membrane or a different class of medication.
Anaphylactoid reactions 25mg membrane exposure.
The high dose in these studies is times the maximum recommended human dose of mg, assuming a 50 kg subject. On a body-surface-area basis, the high doses for mice and rats are 13 and 26 times the maximum recommended human dose, respectively. Studies in rats have revealed no impairment of fertility.
Nursing Mothers Concentrations of captopril in human milk are approximately one 25mg of those in maternal blood. Because of the potential for serious adverse reactions in nursing infants from captopril, a decision should be made whether to discontinue nursing or to discontinue the drug, thuoc captopril bp 25mg, taking captopril account the importance of Thuoc to the mother.
As with other angiotensin converting enzyme inhibitors, captopril is apparently less effective in lowering blood pressure in black people than in non-blacks, possibly because of a higher prevalence of low-renin states in the thuoc hypertensive population. ACE inhibitors should captopril be initiated during pregnancy, thuoc captopril bp 25mg. Unless continued ACE inhibitor therapy is considered essential, patients planning pregnancy should be changed to alternative antihypertensive treatments which have an established safety profile for use in pregnancy.
When pregnancy is diagnosed, treatment with ACE inhibitors should be stopped immediately, and, if thuoc, alternative therapy should be started.
Prior treatment with high dose diuretics may result in volume depletion and a risk of hypotension when initiating therapy with captopril see section 4, thuoc captopril bp 25mg. The hypotensive effects can 25mg reduced by discontinuation of the diuretic, by increasing volume or salt intake or by initiating therapy with a captopril dose of captopril.
However, no clinically significant drug 25mg have been found in specific studies with hydrochlorothiazide or furosemide. Potassium sparing diuretics or potassium supplements: ACE inhibitors attenuate diuretic induced potassium loss.
Potassium-sparing diuretics triamterene, amiloride and spironolactone25mg salt substitutes or potassium supplements may cause significant increase in thuoc potassium, thuoc captopril bp 25mg.
If concomitant use is indicated because of demonstrated hypokalaemia they should be used with caution and with frequent monitoring of serum potassium see section 4. Captopril has been thuoc co-administered with other commonly used anti-hypertensive agents e.
Concomitant use of these agents may increase the hypotensive effects of captopril. Treatment with nitroglycerine and other nitrates, or other vasodilators 25mg as minoxidilshould be used with caution.
Treatments of acute myocardial infarction: Reversible increases in serum captopril concentrations and toxicity have been reported during concomitant administration of lithium with ACE inhibitors. Therefore, caution should be used in patients treated with ACE captopril undergoing such desensitisation procedures.
In these patients, consideration should be given to using a different type of dialysis membrane or a different class of medication. If hypotension occurs, it may be corrected by volume expansion.
As with captopril angiotensin converting enzyme inhibitors, Capozide is apparently less effective in lowering blood pressure in black people than in non-blacks, possibly because of higher thuoc of low-renin states in the black hypertensive population.
Cumulative 25mg of the drug may develop in patients with impaired renal function.
If progressive renal impairment captopril evident, as indicated by captopril rising non-protein nitrogen, careful reappraisal of therapy is necessary, with consideration given to thuoc diuretic therapy see section 4, thuoc captopril bp 25mg. Metabolic and endocrine effects: In diabetic patients dosage adjustments of insulin or oral 25mg agents may be required. Latent diabetes mellitus may become manifest during thiazide therapy. Increases in cholesterol 25mg triglyceride levels have been associated with thiazide diuretic thuoc.
Hyperuricaemia may occur or frank gout may be precipitated in certain patients receiving thiazide therapy. Thiazides, including hydrochlorothiazide, can cause fluid or electrolyte imbalance hypokalaemia, hyponatraemia, and hypochloraemic alkalosis. Warning signs of fluid or electrolyte imbalance are dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pain or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such captopril nausea or vomiting, thuoc captopril bp 25mg.
Although hypokalaemia may develop with the use of thuoc diuretics, concurrent therapy 25mg captopril may reduce diuretic-induced hypokalaemia. The risk of hypokalaemia is greatest in patients with cirrhosis of the liver, in patients experiencing brisk diuresis, in patients who are receiving inadequate oral intake of electrolytes and in patients receiving concomitant therapy with corticosteroids or ACTH see section 4.
Systemic corticosteroids have been associated with blood dyscrasias in patients with renal failure who were also taking captopril.
Induce decreased bioavailability of captopril. In the presence of probenecid, the renal clearance of captopril is reduced. Enhances the hypotensive effect.
Clinical Chemistry Captopril may cause a false-positive 25mg test for acetone, thuoc captopril bp 25mg. The use of ACE inhibitors thuoc not recommended during the first trimester of pregnancy see section 4. Captopril pharmacokinetic data demonstrate very low concentrations in breast milk see section 5.
Avoid driving vehicles or operating machinery until the effects of the drug are established, as it may cause weariness, dizziness and fainting. Although captopril may be used to prevent kidney problems or treat people who have kidney problems, it may also rarely cause serious kidney problems or make them worse.
Your doctor will check your kidney function while you are taking captopril.
Tell your doctor right away if you have any signs of kidney problems such as a change in the amount of urine. This drug may 25mg cause 25mg possibly fatal liver problems.
Tell your doctor right away if you notice any of the following rare but serious side effects: A very serious allergic reaction to this captopril is rare. However, thuoc captopril bp 25mg, get medical help right away if you notice any of the following symptoms of a serious allergic reaction: Captopril is not a complete list of possible side effects.
If you notice other effects not listed above, thuoc your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects, thuoc captopril bp 25mg. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Thuoc Canada at
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